Healing

TB-500

Not approved; no controlled human trialsMostly animal studiesTB500Thymosin beta-4TB4

A short synthetic piece (7 amino acids) of thymosin beta-4, a natural protein involved in cell movement and wound repair. Most evidence is from animal studies of the full protein, which isn't the same molecule. There are no controlled human trials of TB-500 itself.

Canada
Not authorized; named in Health Canada's 2026 warning
United States
Not approved. Removed from Category 2 in Apr 2026; advisory committee voted to allow compounding in Jul 2026; no final rule

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Not medical advice — talk to your doctor before making medical decisions.

At a glance

Class
Healing peptide
Mechanism
Proposed: cell migration, new blood vessels, less inflammation (animal data on thymosin beta-4)
Evidence
Animal data; small human trials of the full protein only
Canada
Not authorized
Us
Not approved
Half Life
Unknown
Routes
SubQ
Common Side Effects
Few reported; tiredness, headache, site irritation in anecdotes
Key Cautions
Unknown long-term safety; theoretical tumour-growth concern

What the research says

  • Does it work in people?

    Unknown. Small phase 2 trials of full thymosin beta-4 (eye and skin wounds) gave mixed results. A 2024 study suggested TB-500 itself may not speed wound healing and that a breakdown product does the work.

  • Is "TB-500" the same as thymosin beta-4?

    No. Vendors often use the names interchangeably, but TB-500 is a 7-amino-acid fragment and research on the full 43-amino-acid protein doesn't transfer directly.

  • With BPC-157?

    Commonly paired for injuries, sometimes in one blend vial. No human data on the combination.

  • If you're drug-tested in sport?

    Prohibited by WADA at all times. A Canadian athlete received a four-year ban involving BPC-157 and TB-500.

Get medical care if

  • Redness, heat, swelling or pus at a site that spreads or comes with fever
  • Hives, swelling of the face or throat, or trouble breathing (call 911)

Buying and quality

  • Not authorized by Health Canada. Products sold online as "research use only" are illegal to sell for human use in Canada, and the label doesn't change that.
  • Health Canada warns these products may contain too much, too little or none of the peptide, plus contaminants like endotoxins, solvents, heavy metals or bacteria.
  • A certificate of analysis (COA) from the seller isn't independent proof. A 98% purity result still leaves 2% unidentified.
  • If you use it anyway: one clean needle per injection, sterile technique, label and date every vial, and stop if a site gets hot, red and spreading.

Dose calculator

Doses are set with your prescriber. This converts a dose you already have into what to draw; it doesn't recommend one. Check every number against your syringe and your vial's label.

Doses left in the vial
A blend vial

Not medical advice — talk to your doctor before making medical decisions.

Sources

Researched 2026-10-27. Trial results and approval status change.

  1. BSCG: TB-500 status, risks and bans in sport and military
  2. Health Canada: Think twice before injecting peptides bought online (Apr 9, 2026)
  3. FDA Pharmacy Compounding Advisory Committee
  4. PubMed: thymosin beta-4 studies
  5. ClinicalTrials.gov: thymosin beta 4

General education, not medical advice. Nothing here is a dose recommendation. Doses, schedules and changes are set with a prescriber.