Mitochondrial
SS-31
Approved for Barth syndrome (US)Approved drugElamipretideForzinity
A small peptide that targets the inner membrane of mitochondria. As elamipretide (Forzinity), it became the first approved treatment for Barth syndrome, a rare genetic disease, in 2025. Trials in other conditions, like primary mitochondrial myopathy and heart failure, didn't meet their main goals.
- Canada
- Not authorized; named in Health Canada's 2026 warning
- United States
- Elamipretide (Forzinity) got accelerated approval in Sep 2025 for Barth syndrome only
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Not medical advice — talk to your doctor before making medical decisions.
At a glance
- Class
- Mitochondrial
- Mechanism
- Binds cardiolipin in mitochondria to support energy production
- Evidence
- Approved for a rare disease; failed trials elsewhere
- Canada
- Not authorized
- Us
- Approved (Forzinity) for Barth syndrome only
- Half Life
- A few hours
- Routes
- SubQ
- Common Side Effects
- Site reactions are the most common in trials
- Key Cautions
- No evidence of benefit in healthy people
What the research says
Approved for what?
Only Barth syndrome, a rare inherited disease, under FDA accelerated approval (September 2025).
For energy, longevity or performance?
No trials in healthy people. A phase 3 trial in primary mitochondrial myopathy didn't meet its main goal.
Side effects?
In trials, injection-site reactions were the most common, often frequent.
Get medical care if
- Redness, heat, swelling or pus at a site that spreads or comes with fever
- Hives, swelling of the face or throat, or trouble breathing (call 911)
Buying and quality
- Not authorized by Health Canada. Products sold online as "research use only" are illegal to sell for human use in Canada, and the label doesn't change that.
- Health Canada warns these products may contain too much, too little or none of the peptide, plus contaminants like endotoxins, solvents, heavy metals or bacteria.
- A certificate of analysis (COA) from the seller isn't independent proof. A 98% purity result still leaves 2% unidentified.
- If you use it anyway: one clean needle per injection, sterile technique, label and date every vial, and stop if a site gets hot, red and spreading.
Dose calculator
Doses are set with your prescriber. This converts a dose you already have into what to draw; it doesn't recommend one. Check every number against your syringe and your vial's label.
Doses left in the vial
A blend vial
Not medical advice — talk to your doctor before making medical decisions.
Sources
Researched 2026-10-27. Trial results and approval status change.
General education, not medical advice. Nothing here is a dose recommendation. Doses, schedules and changes are set with a prescriber.